منابع مشابه
Development and Evaluation of Metoprolol Tartrate Chronotherapeutic Drug Delivery System
In the present research work pulsatile drug delivery system of Metoprolol tartrate tablets were formulated and developed by employing compression coating technology. Initially the core tablets were prepared by using various concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and press coated table...
متن کاملA Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery
A Multilayered Multidisk Tablet (MLMDT) comprising two drug-loaded disks enveloped by three drug-free barrier layers was developed for use in chronotherapeutic disorders, employing two model drugs, theophylline and diltiazem HCl. The MLMDT was designed to achieve two pulses of drug release separated by a lag phase. The polymer disk comprised hydroxyethylcellulose (HEC) and ethylcellulose (EC) g...
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Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Meth...
متن کاملDesign and optimization of self-microemulsifying drug delivery system (SMEDDS) of felodipine for chronotherapeutic application
The objective of this research work was to design, develop and optimize the self micro-emulsifying drug delivery system (SMEDDS) of Felodipine (FL) filled in hard gelatine capsule coated with polymer in order to achieve rapid drug release after a desired time lag in the management of hypertension. Microemulsion is composed of a FL, Lauroglycol FCC, Transcutol P and Cremophor EL. The optimum sur...
متن کاملDesign and in Vitro Evaluation of Eudragit® S100/Lipid Based Simvastatin Chronotherapeutic Drug Delivery System
The present study was undertaken to 1) formulate a pulsatile colonic delivery of simvastatin (SIM) as chronotherapy for treatment of hypercholesterolemia, and 2) enhance the dissolution profile of the prepared SIM chronotherapeutic system. Lipid based formulations were utilized to formulate SIM in capsule dosage form coated with Eudragit® S100. SIM was formulated using different percentages of ...
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ژورنال
عنوان ژورنال: Journal of Drug Metabolism & Toxicology
سال: 2015
ISSN: 2157-7609
DOI: 10.4172/2157-7609.1000194